myDNAid - PGx

Clinical Resource for Healthcare Providers

Doctors Corner

Precision pharmacogenomics at the point of care. The myDNAid PGx card puts critical drug-gene interaction data in your patients' hands—ready for immediate clinical decision-making.

Clinical Utility

⚠️

Emergency Medicine

Instant access to critical contraindications in emergency situations:

  • • Malignant hyperthermia susceptibility (RYR1, CACNA1S)
  • • Opioid metabolism risks (CYP2D6 poor/ultra-rapid metabolizers)
  • • Antiplatelet therapy failures (CYP2C19 poor metabolizers)
  • • Severe cutaneous adverse reaction risks (HLA variants)
💊

Chronic Disease Management

Optimize medication selection and dosing for:

  • • Antidepressants and antipsychotics (CYP2D6, CYP2C19, CYP1A2)
  • • Anticoagulants (CYP2C9, VKORC1 for warfarin)
  • • Statins (SLCO1B1 for myopathy risk)
  • • Beta-blockers (ADRB1 for response prediction)
🎗️

Oncology

Prevent life-threatening toxicities from chemotherapy:

  • • Fluoropyrimidine toxicity (DPYD deficiency)
  • • Thiopurine myelosuppression (TPMT, NUDT15)
  • • Irinotecan toxicity (UGT1A1*28)
  • • Tamoxifen efficacy (CYP2D6 metabolism)
🦠

Infectious Diseases

Optimize antimicrobial therapy:

  • • Efavirenz CNS toxicity (CYP2B6)
  • • Abacavir hypersensitivity (HLA-B*57:01)
  • • Voriconazole dosing (CYP2C19)

How It Works in Clinical Practice

Patient Presents Card

Patient presents their myDNAid PGx card during consultation or emergency visit.

Scan QR Code

Scan the QR code on the front of the card using any smartphone. This directs you to our secure decrypt portal.

Request Access

Enter your contact information (phone number) to request access. A 6-digit OTP is sent via SMS to your phone number.

Patient Notification & Access

The patient receives SMS notifications that a decryption request was made and by which phone number. You then enter the OTP you received to decrypt the patient's PGx data.

Instant Decryption

Once authorized, you instantly see the patient's complete PGx profile including:

  • • Known diagnosis and important clinical notes
  • • Next of kin / emergency contact information
  • • Top 3 emergency alerts (critical contraindications)
  • • Anesthesia emergency genes (malignant hyperthermia risk)
  • • Complete drug-gene interactions by therapeutic area

Audit Trail

The patient receives SMS notifications confirming that you accessed their record, ensuring full transparency and audit compliance.

What's on the Card

Patient Clinical Summary

Clinical Context

  • • Known diagnosis (e.g., Type 2 Diabetes, Hypertension)
  • • Important clinical notes
  • • Next of kin / emergency contact

Emergency Alerts

  • • Top 3 contraindicated drugs
  • • Malignant hyperthermia susceptibility
  • • Safe alternative medications

Pharmacogenomic Data

Complete drug-gene interaction data organized by therapeutic area:

Anesthesia & Emergency

CYP2D6, CYP2C19, RYR1, CACNA1S, G6PD

Cardiovascular

CYP2C9, VKORC1, SLCO1B1, CYP2D6, ADRB1

Pain Management

CYP2D6, CYP2C9, CYP2C19, COMT, OPRM1

Psychiatry & Neurology

CYP2D6, CYP2C19, CYP1A2, MTHFR, SLC6A4, HTR2A, HLA-B*15:02, HLA-A*31:01

Infectious Diseases

CYP2B6, HLA-B*57:01, CYP2C19

Total Genes

19 critical pharmacogenes

Clinical Interpretation Guide

Phenotype Classifications

Poor Metabolizer (PM)

Significantly reduced or absent enzyme activity. Risk of drug accumulation and toxicity. Consider dose reduction or alternative medication.

Intermediate Metabolizer (IM)

Reduced enzyme activity. May require dose adjustment. Monitor for adverse effects.

Normal Metabolizer (NM)

Standard enzyme activity. Standard dosing appropriate.

Rapid/Ultra-rapid Metabolizer (RM/UM)

Increased enzyme activity. Risk of therapeutic failure due to rapid drug clearance. Consider alternative medication or dose increase.

Key Clinical Actions

⚠️ Avoid Drug

Drug is contraindicated due to high risk of adverse reaction or lack of efficacy. Use safe alternatives listed.

💊 Dose Adjustment

Drug can be used but requires dose modification based on metabolizer status. Follow CPIC guidelines.

🔬 Alternative Medication

Safer or more effective alternatives are available. Consider switching to recommended alternatives.

📊 Monitor Closely

Drug can be used with standard dosing but requires enhanced therapeutic drug monitoring or clinical monitoring.

Beyond PGx: Comprehensive Genetic Testing

The myDNAid PGx card focuses on 19 critical pharmacogenes for immediate medication safety. However, patients' whole genomes contain over 20,000 genes with clinical relevance across multiple conditions.

🩺 MyDNAid-Clin

Comprehensive clinical genetic screening for:

  • • Hereditary cancers (BRCA1/2, Lynch syndrome, etc.)
  • • Cardiomyopathies and arrhythmias
  • • Rare genetic diseases
  • • Carrier screening for family planning

Requires genetic counseling and doctor's referral

🧬 MyDNAid-Gmx

Complete genomic analysis including:

  • • Full raw genomic data
  • • Deep ancestry insights
  • • Comprehensive trait analysis
  • • Future-proof data for emerging research

Requires genetic counseling and doctor's referral

💡 Re-Analysis for Existing PGx Patients

Patients who already have PGx data with us can get comprehensive re-analysis of all 10,000+ remaining genes for USD $100 - $150 per condition, depending on the number of genes involved.

Clinical Support & Consultation

For inquiries about available tests and further explanations, contact us on:

📧

Email

inquiries@nextgenmolecularlab.com

🏥

Location

Roslyn Riviera Mall, 3rd Floor
Limuru Rd, Nairobi

Clin & Gmx require doctor's referral. PGx is available direct-to-consumer.